1-[(2-Hydroxyethoxy)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione(CAS: 68724-11-8)

1-[(2-Hydroxyethoxy)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione is a white crystalline solid with a molecular weight of approximately 238.23 g/mol. It has poor solubility in water but is soluble in organic solvents. The compound is relatively stable but can react with strong oxidizing agents. It is often used as a starting material in organic synthesis due to its reactive functional groups.

1-[(2-Hydroxyethoxy)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione is typically synthesized by the condensation of 2-hydroxyethylamine with 5-methyl-2,4-dione. This reaction is catalyzed by a base such as potassium carbonate, and the yield is generally excellent with high purity. The reaction is carried out in an organic solvent like dimethylformamide (DMF).

1-[(2-Hydroxyethoxy)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione is extensively used in the pharmaceutical industry as a precursor in the synthesis of various drug molecules. It also finds applications in the polymer industry for modifying polymer properties and in the production of semiconductors due to its electronic properties.

When handling 1-[(2-Hydroxyethoxy)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.