Fmoc-Val-Ala-PAB-OH(CAS: 1394238-91-5)

Fmoc-Val-Ala-PAB-OH is a solid with a crystalline form. Its molecular weight is approximately 415.35 g/mol. It is sparingly soluble in water and more soluble in organic solvents. This compound is known for its reactivity in peptide coupling reactions, particularly in solid-phase peptide synthesis.

Fmoc-Val-Ala-PAB-OH is synthesized through solid-phase peptide synthesis using Fmoc chemistry. The process involves coupling the amino acid Val-Ala-PAB to a solid support, followed by deprotection with hydroxylamine to introduce the PAB group. Commonly used reagents include Fmoc-protected amino acids and coupling agents like HBTU or DIC.

Fmoc-Val-Ala-PAB-OH is primarily used in the pharmaceutical industry for the synthesis of peptide drugs. It is also utilized in the development of biosensors and in the production of peptides for research purposes. Its application in polymer chemistry and semiconductor manufacturing is limited due to its specific reactivity in peptide coupling reactions.

When handling Fmoc-Val-Ala-PAB-OH, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate solvents, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.