(17alpha)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one(CAS: 5630-53-5)

(17alpha)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one is a white to off-white crystalline solid with a molecular weight of approximately 330.46 g/mol. It has limited water solubility, typically requiring solvents like methanol or ethanol for dissolution. The compound is relatively stable under normal conditions but can degrade under acidic or basic conditions. It exhibits low reactivity towards common functional groups but can undergo reactions such as reduction or aromatization with appropriate reagents.

(17alpha)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one is commonly synthesized through a series of reactions starting from a suitable steroidal precursor. The process involves hydroxylation, methylation, and alkynylation steps. Palladium catalysts are often used for the arylation and hydroxylation reactions, achieving high selectivity and yield. The final product is purified through recrystallization or column chromatography.

(17alpha)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one is primarily used in the pharmaceutical industry for the synthesis of progestins and other hormonal compounds. It is also utilized in the production of certain sensors and as a research reagent in various scientific fields, including materials science and organic chemistry.

When handling (17alpha)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and lab coats to protect the skin and clothing. Work should be conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately using appropriate solvents and ensure proper disposal according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and storage instructions.