2,3-Dihydro-1-benzofuran-5-ylacetic acid(CAS: 69999-16-2)

2,3-Dihydro-1-benzofuran-5-ylacetic acid is a white or off-white crystalline solid with a molecular weight of approximately 248.24 g/mol. It has a slight pungent odor. This compound is soluble in ethanol, chloroform, and methanol but poorly soluble in water. It is an electrophilic compound and exhibits moderate reactivity under basic conditions, making it suitable for various synthetic transformations. The compound can form anhydrous crystalline forms and has a melting point around 215-217°C.

2,3-Dihydro-1-benzofuran-5-ylacetic acid can be synthesized through a multi-step process involving the condensation of an appropriate aromatic compound with acetic anhydride. A typical synthesis involves the reaction of 5-benzofuranone with acetic anhydride in the presence of an acid catalyst, such as sulfuric acid. The product is then isolated by recrystallization from an appropriate solvent. The yield is generally around 75-85%, with high selectivity and purity.

2,3-Dihydro-1-benzofuran-5-ylacetic acid is used in various industries due to its versatile chemical properties. It is primarily used in the pharmaceutical sector for the synthesis of certain drug intermediates. Additionally, it finds applications in the development of sensors for detecting specific analytes, as well as in the production of certain polymers and materials. Its use in semiconductors and electronic devices is also being explored for its potential in organic electronics.

When handling 2,3-Dihydro-1-benzofuran-5-ylacetic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat. The compound should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, it is recommended to use absorbent materials and dispose of the waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information. This compound is not reactive under normal conditions but should be handled with care to avoid inhaling dust or fumes.