1-[4-(Trifluoromethoxy)phenyl]ethanone(CAS: 85013-98-5)

1-[4-(Trifluoromethoxy)phenyl]ethanone (CAS: 85013-98-5) is a crystalline solid with a molecular weight of approximately 256.1 g/mol. It has low solubility in water but is more soluble in organic solvents like dichloromethane and acetonitrile. Chemically, it is stable at room temperature but can react with strong bases. It shows poor reactivity towards nucleophiles and electrophiles, making it useful in various synthetic applications.

1-[4-(Trifluoromethoxy)phenyl]ethanone (CAS: 85013-98-5) is commonly synthesized via a Friedel-Crafts acylation reaction. The process involves the reaction of p-toluidine with trifluoromethoxyacetyl chloride in the presence of aluminum chloride as a catalyst. The reaction yields a high purity product with good selectivity and moderate to high yield.

1-[4-(Trifluoromethoxy)phenyl]ethanone (CAS: 85013-98-5) is used in the pharmaceutical industry for the synthesis of complex organic molecules and as a precursor in the development of novel drugs. It is also relevant in the polymer industry for the formation of functional materials with enhanced properties. Additionally, it finds applications in the field of sensors and semiconductors for its unique chemical properties.

Proper handling of 1-[4-(Trifluoromethoxy)phenyl]ethanone (CAS: 85013-98-5) is essential due to its chemical nature. Always wear appropriate personal protective equipment (PPE) including gloves, goggles, and laboratory coat. Ensure adequate ventilation in the work area, and use a fume hood during handling. Store the compound in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. In case of a spill, consult the Safety Data Sheet (SDS) for appropriate clean-up procedures.