4-Bromo-2-methyl-6-nitroaniline(CAS: 77811-44-0)

4-Bromo-2-methyl-6-nitroaniline is a white solid with a molecular weight of approximately 244.03 g/mol. It has a pKa of around 8.8 and is slightly soluble in water. This compound is known for its reactivity, particularly towards nucleophilic substitution reactions and reduction. It is often used in organic synthesis and as a precursor in the development of dyes and pharmaceuticals.

4-Bromo-2-methyl-6-nitroaniline is typically synthesized by the nitration of 4-bromo-2-methylaniline, followed by bromination. Common methods involve the use of nitric acid and sulfuric acid as reagents, with temperatures ranging from 0 to 20°C. The reaction is carried out under anhydrous conditions to enhance selectivity. Yield and purity are generally high, making this a reliable synthetic route.

4-Bromo-2-methyl-6-nitroaniline is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of drugs. It also finds applications in the polymer industry for the development of dyes and pigments. Additionally, it is used in the electronics sector for the production of sensors and semiconductors due to its electronic properties.

Handling 4-Bromo-2-methyl-6-nitroaniline requires strict safety measures. It should be stored in a cool, dry place away from heat sources and incompatible materials. Always use appropriate personal protective equipment (PPE), such as gloves and safety goggles. Work should be carried out in a well-ventilated area or fume hood to minimize exposure. In case of a spill, immediately clean up with suitable absorbent materials and follow the safety data sheet (SDS) for further instructions.