Ethyl 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylate(CAS: 163520-33-0)

Ethyl 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylate is a crystalline compound with a molecular weight of approximately 410.4 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetone. Chemically, it is relatively stable but can react with strong bases to form salts. It shows weak acidity and can participate in nucleophilic substitution reactions.

Ethyl 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylate is typically synthesized from ethyl 3-carbamoylbenzoate and phenylhydrazine. The reaction involves the condensation of the carboxylic acid derivative with the amine to form the oxazole ring. Commonly, this is achieved in the presence of a base like triethylamine, with an overall yield of around 75-80%. The reaction is carried out under mild conditions and can be optimized for better selectivity and yield.

Ethyl 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylate is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the development of antiviral and anti-inflammatory drugs. Additionally, it serves as a building block in the production of polymers with specific thermal and mechanical properties. It is also utilized in the preparation of sensors and in the semiconductor industry for its unique electronic properties.

When handling Ethyl 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylate, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be stored in a tightly sealed container in a cool, dry place away from direct sunlight. In case of a spill, it should be handled in a well-ventilated area using appropriate containment. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.