2-(Chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole(CAS: 723286-98-4)

2-(Chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole is a white crystalline solid with a molecular weight of approximately 205.03 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and ethanol. Chemically, it is highly reactive, particularly due to its oxadiazole ring, which can participate in various electrophilic and nucleophilic reactions. It is an important intermediate in the synthesis of pharmaceuticals and other functional materials.

2-(Chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole is typically synthesized via the reaction of 5-chloromethyl-1,3,4-oxadiazole with trifluoroacetyl chloride. The reaction is performed in the presence of a base such as triethylamine. The yield is generally good, and the selectivity is high, making this a reliable method for preparing this compound.

2-(Chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole is primarily used in the pharmaceutical and polymer industries. It serves as a key precursor in the synthesis of various drug molecules and can also be used as a building block in the preparation of functional polymers. Additionally, its unique chemical properties make it valuable in the development of sensors and semiconductor materials.

When handling 2-(Chloromethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials, and proper disposal methods should be followed. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.