Resmetirom(CAS: 920509-32-6)

Resmetirom is a cyclic guanidine derivative with a molecular weight of approximately 272.29 g/mol. It is a white, crystalline solid with a melting point around 250°C. Resmetirom is slightly soluble in water and organic solvents such as ethanol and acetonitrile. It exhibits moderate reactivity towards strong acids and bases and is stable under normal conditions, but should be stored away from strong oxidizing agents.

Resmetirom is synthesized through a multi-step reaction involving the condensation of guanidine with a cyclic carbonate in the presence of a base. The key steps include protection of the guanidine nitrogen, cyclization, and deprotection. The synthesis involves the use of triethylamine and tetrahydrofuran (THF) as a solvent. The overall yield is around 50%, and the reaction is highly selective and efficient.

Resmetirom is primarily used in the pharmaceutical industry for the treatment of primary hyperthyroidism. It is also of interest in research for its ability to inhibit the receptor activator of nuclear factor κB ligand (RANKL) and may have applications in osteoporosis and other bone-related conditions. It is not used in polymer, semiconductor, or sensor industries.

When handling Resmetirom, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. It should be stored in a cool, dry place away from strong oxidizers and acids. In case of a spill, it should be cleaned up using a suitable absorbent material and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.