Compound Q&A
How is Resmetirom (CAS: 920509-32-6) typically synthesized?
Answer
Resmetirom is synthesized through a multi-step reaction involving the condensation of guanidine with a cyclic carbonate in the presence of a base. The key steps include protection of the guanidine nitrogen, cyclization, and deprotection. The synthesis involves the use of triethylamine and tetrahydrofuran (THF) as a solvent. The overall yield is around 50%, and the reaction is highly selective and efficient.
About
CAS No
920509-32-6
English Name
Resmetirom
Molecular Formula
C17H12Cl2N6O4
Molecular Weight
435.22 g/mol
SMILES
CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
InChIKey
FDBYIYFVSAHJLY-UHFFFAOYSA-N
Last Updated: 2025-10-16 16:48
