[3-Chloro-5-(4-morpholinylcarbonyl)phenyl]boronic acid(CAS: 957120-55-7)

[3-Chloro-5-(4-morpholinylcarbonyl)phenyl]boronic acid is a crystalline solid with a molecular weight of approximately 323.28 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and acetonitrile. This compound exhibits moderate reactivity in organic synthesis, particularly in boronate ester formation. It is stable under standard storage conditions but should be protected from strong oxidizing agents and moisture.

[3-Chloro-5-(4-morpholinylcarbonyl)phenyl]boronic acid is typically synthesized by coupling 3-chlorophenylboronic acid with 4-(carbonyl)-4-morpholinyl boronic acid in the presence of a palladium catalyst (e.g., Pd(PPh3)4) and a base (e.g., potassium carbonate). The reaction is carried out in an organic solvent like toluene or dioxane at elevated temperatures. High selectivity and yields can be achieved under optimized conditions.

[3-Chloro-5-(4-morpholinylcarbonyl)phenyl]boronic acid finds applications in various industries, particularly in pharmaceuticals for the synthesis of drug intermediates. It is also used in the development of sensors and materials for semiconductors. This compound is valuable for its unique chemical properties, making it a key reagent in organic synthesis.

When handling [3-Chloro-5-(4-morpholinylcarbonyl)phenyl]boronic acid, it is essential to use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate cleaning agents and waste should be disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.