(2-Chloro-3-pyridinyl)boronic acid(CAS: 381248-04-0)

(2-Chloro-3-pyridinyl)boronic acid (CAS: 381248-04-0) is a crystalline solid with a molecular weight of approximately 193.04 g/mol. It has a solubility of 1.05 g/L in water. Chemically, it is highly reactive towards nucleophiles and is commonly used in Suzuki coupling reactions. It is stable under normal temperature and pressure conditions but should be stored away from moisture and heat to prevent hydrolysis.

(2-Chloro-3-pyridinyl)boronic acid (CAS: 381248-04-0) is typically synthesized via the condensation of 2-chloro-3-pyridineboronic anion with a suitable alcohol or phenol. Common methods include the use of boronic acids with diisopropyl azodicarboxylate (DIAD) and triphenylphosphine (Ph3P) as a catalyst. The yield is generally high, and the reaction is known for its good regioselectivity and chemoselectivity.

(2-Chloro-3-pyridinyl)boronic acid (CAS: 381248-04-0) is used in various industries, primarily in pharmaceuticals and organic synthesis. It plays a crucial role in the synthesis of complex organic molecules, particularly in the development of new drugs. Additionally, it is utilized in the production of polymers and as a reagent in analytical chemistry for the detection of various compounds.

When handling (2-Chloro-3-pyridinyl)boronic acid (CAS: 381248-04-0), it is essential to wear chemical-resistant gloves, protective goggles, and a lab coat to prevent skin contact and eye irritation. It should be stored in a cool, dry place away from moisture and heat. In the event of a spill, use appropriate PPE and clean up with care. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal guidelines.