Diethyl [(4-chlorobenzoyl)amino]malonate(CAS: 81918-01-6)

Diethyl [(4-chlorobenzoyl)amino]malonate is a white crystalline solid with a molecular weight of approximately 322.18 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. Chemically, it is highly reactive, particularly towards nucleophiles, and it can undergo various reactions such as esterification and amidation.

Diethyl [(4-chlorobenzoyl)amino]malonate is typically synthesized by the reaction of ethyl malonate with 4-chlorobenzoyl chloride in the presence of a tertiary amine like triethylamine as a base. The reaction is conducted at room temperature, and the product is isolated by recrystallization from an appropriate solvent.

Diethyl [(4-chlorobenzoyl)amino]malonate (CAS: 81918-01-6) is primarily used in the pharmaceutical industry for the synthesis of certain intermediates and in the polymer industry for the production of speciality polymers. It also finds applications in the sensor and semiconductor industries as a precursor for functional materials.

When handling Diethyl [(4-chlorobenzoyl)amino]malonate (CAS: 81918-01-6), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to minimize exposure to chlorine-containing vapor. Spills should be cleaned up with appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for specific handling and storage guidelines.