4-Bromo-N-phenylaniline(CAS: 54446-36-5)

4-Bromo-N-phenylaniline (CAS: 54446-36-5) is a crystalline solid with a molecular weight of approximately 236.17 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it shows good reactivity towards nucleophiles and electrophiles, making it useful in various synthetic transformations. It is stable under normal conditions but should be protected from moisture and air to prevent degradation.

4-Bromo-N-phenylaniline is typically synthesized by reacting anisidine with bromine in the presence of an appropriate Lewis acid catalyst, such as aluminum bromide. The reaction provides good yield and selectivity, with the key step involving electrophilic aromatic substitution. The product can then be purified by recrystallization or other chromatographic techniques.

4-Bromo-N-phenylaniline (CAS: 54446-36-5) is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds applications in the polymer industry for the production of specific polymers and in the development of sensors due to its reactivity and stability under specific conditions. Additionally, it is utilized in the semiconductor industry for its unique electronic properties.

When handling 4-Bromo-N-phenylaniline (CAS: 54446-36-5), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and lab coats to protect against potential skin and eye contact. The substance should be stored in a fume hood or a well-ventilated area to minimize inhalation risks. In case of spill, immediately clean up with appropriate absorbent materials and ensure proper disposal. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.