5-Ethyl-5-phenyl-2,5-dihydro-4,6-pyrimidinediol(CAS: 125-33-7)

5-Ethyl-5-phenyl-2,5-dihydro-4,6-pyrimidinediol (CAS: 125-33-7) is a white crystalline solid with a molecular weight of approximately 232.25 g/mol. It has a high solubility in polar solvents such as methanol and ethanol but is less soluble in water. This compound is relatively stable under normal conditions but can react with strong acids and bases. It is also known for its reactivity towards nucleophiles and electrophiles, making it a useful reagent in organic synthesis.

5-Ethyl-5-phenyl-2,5-dihydro-4,6-pyrimidinediol can be synthesized via the condensation of 5-ethynyl-2,4,6-pyrimidinetrione with phenylacetylene. This method involves the use of sodium hydride as a catalyst. The reaction is carried out in a suitable solvent such as THF. The yield is typically around 70-80%, and the product is isolated by column chromatography. This synthesis is selective and efficient, making it a common method in the laboratory.

5-Ethyl-5-phenyl-2,5-dihydro-4,6-pyrimidinediol (CAS: 125-33-7) is primarily used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It is also applied in the production of polymers, sensors, and semiconductors due to its unique chemical properties. Its ability to form stable complexes and its reactivity make it a valuable compound in these industries.

When handling 5-Ethyl-5-phenyl-2,5-dihydro-4,6-pyrimidinediol (CAS: 125-33-7), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. The compound should be stored in a cool, dry place away from direct sunlight. It should be handled in a well-ventilated area or a fume hood to prevent inhalation. In case of a spill, it is recommended to use absorbent materials and dispose of the contaminated materials according to local regulations. Always refer to the safety data sheet (SDS) for detailed information on handling and safety measures.