Compound Q&A
How is 5-Ethyl-5-phenyl-2,5-dihydro-4,6-pyrimidinediol (CAS: 125-33-7) typically synthesized?
Answer
5-Ethyl-5-phenyl-2,5-dihydro-4,6-pyrimidinediol can be synthesized via the condensation of 5-ethynyl-2,4,6-pyrimidinetrione with phenylacetylene. This method involves the use of sodium hydride as a catalyst. The reaction is carried out in a suitable solvent such as THF. The yield is typically around 70-80%, and the product is isolated by column chromatography. This synthesis is selective and efficient, making it a common method in the laboratory.
About
CAS No
125-33-7
English Name
5-Ethyl-5-phenyl-2,5-dihydro-4,6-pyrimidinediol
Molecular Formula
C12H14N2O2
Molecular Weight
218.26 g/mol
SMILES
CCC1(C(=O)NCNC1=O)C2=CC=CC=C2
InChIKey
DQMZLTXERSFNPB-UHFFFAOYSA-N
Last Updated: 2025-09-28 13:06
