4-bromo-1H-indazole-6-carboxylic acid(CAS: 885523-43-3)

4-Bromo-1H-indazole-6-carboxylic acid is a crystalline solid with a molecular weight of approximately 256.03 g/mol. It has limited water solubility and is sparingly soluble in common organic solvents. This compound is known for its stability under normal conditions but can react with strong bases to form salts. It exhibits weak acidity due to the carboxylic acid group.

4-Bromo-1H-indazole-6-carboxylic acid is commonly synthesized via the bromination of indazole-6-carboxylic acid followed by a carboxylic acid condensation reaction. The key steps involve the bromination of the indazole ring, which can be achieved using N-bromosuccinimide (NBS) in an appropriate solvent. The product is purified by recrystallization from water or organic solvents.

4-Bromo-1H-indazole-6-carboxylic acid is primarily used in the pharmaceutical and chemical industries for the synthesis of various intermediates and drugs. It also finds applications in the development of specialized polymers, sensors, and materials for semiconductor devices due to its unique chemical properties.

When handling 4-bromo-1H-indazole-6-carboxylic acid, it is essential to wear protective equipment including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be immediately cleaned up with appropriate absorbent material and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.