[3-(Trifluoromethyl)phenyl]boronic acid(CAS: 1423-26-3)

[3-(Trifluoromethyl)phenyl]boronic acid (CAS: 1423-26-3) is a white crystalline solid with a molecular weight of approximately 287.09 g/mol. It is sparingly soluble in water but easily soluble in organic solvents like methanol and ethanol. This compound exhibits good reactivity in boronate ester formation and is commonly used in organic synthesis, particularly in Suzuki coupling reactions.

[3-(Trifluoromethyl)phenyl]boronic acid (CAS: 1423-26-3) is usually synthesized via a boronation reaction of 3-(trifluoromethyl)phenol with a boronate ester or a boronic acid derivative. The reaction often employs a palladium catalyst and a base such as potassium carbonate. The yield can be up to 90%, and the reaction is selective and efficient.

[3-(Trifluoromethyl)phenyl]boronic acid (CAS: 1423-26-3) is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various pharmaceutical compounds and is also utilized in the development of polymer functionalization and modification processes.

When handling [3-(Trifluoromethyl)phenyl]boronic acid (CAS: 1423-26-3), it is essential to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Store the compound in a cool, dry place away from direct sunlight and incompatible materials. In case of spill, clean up immediately using appropriate safety measures and consult a safety data sheet (SDS) for detailed instructions.