Methyl (2E)-[2-(bromomethyl)phenyl](methoxyimino)acetate(CAS: 133409-72-0)

Methyl (2E)-[2-(bromomethyl)phenyl](methoxyimino)acetate is a colorless to light yellow oil at room temperature. Its molecular weight is approximately 352.1 g/mol. It has limited solubility in water but is soluble in organic solvents like ethanol and acetone. This compound is relatively stable under normal conditions but can react with basic substances to form byproducts. It is mildly reactive towards nucleophiles.

Methyl (2E)-[2-(bromomethyl)phenyl](methoxyimino)acetate is typically synthesized via a multi-step process involving the bromination of a phenylacetate followed by a Wittig reaction. The key steps include bromination of the phenyl group, followed by reaction with a methoxyimino compound to form the desired ester. Common catalysts and reagents include NBS (N-bromosuccinimide) and methoxyimino compounds. The overall yield is moderate to good, depending on the purity of starting materials and reaction conditions.

Methyl (2E)-[2-(bromomethyl)phenyl](methoxyimino)acetate is primarily used in the pharmaceutical industry for synthesizing certain drug precursors. It also finds applications in the polymer industry for functionalizing polymers. Additionally, it can be used in the production of sensors and as a precursor in semiconductor manufacturing processes for specific chemical treatments.

When handling Methyl (2E)-[2-(bromomethyl)phenyl](methoxyimino)acetate, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be used in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up using appropriate absorbent materials and a spill kit. The material safety data sheet (MSDS) should be consulted for detailed safety information and emergency procedures. Storage should be at room temperature away from sources of heat and light.