2-ethynylaniline(CAS: 52670-38-9)

2-Ethynylaniline is a colorless to pale yellow solid with a molecular weight of approximately 112.14 g/mol. It has a melting point of 48-49°C and is slightly soluble in water. It is highly reactive due to the presence of a -CN group and a -C≡C- group. The compound is also sensitive to light and air oxidation.

2-Ethynylaniline can be synthesized via the reaction of aniline with acetylene in the presence of a copper catalyst. The reaction involves electrophilic aromatic substitution and can be carried out under mild conditions. The yield is generally good, and the selectivity is high due to the presence of a strong electron-withdrawing group.

2-Ethynylaniline finds applications in the pharmaceutical industry for the synthesis of certain drugs and intermediates. It is also used in the production of dyes, pigments, and other chemical intermediates. Additionally, this compound can be utilized in the development of sensors and as a precursor in the semiconductor industry.

When handling 2-ethynylaniline, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to avoid inhaling vapors. Spills should be cleaned up using appropriate absorbent materials, and the area should be decontaminated. Always consult the Safety Data Sheet (SDS) for detailed safety information.