(1R,2R,3S,4S,5S,6S)-1,2,3,4,5,6-Cyclohexanehexol(CAS: 643-12-9)

(1R,2R,3S,4S,5S,6S)-1,2,3,4,5,6-Cyclohexanehexol, also known as 1,2,3,4,5,6-Cyclohexanetetrol, is a colorless crystalline solid with a molecular weight of approximately 158.23 g/mol. It has a low solubility in water but is more soluble in organic solvents. This compound is relatively stable under normal conditions but can react with strong acids or bases. It is used in various applications due to its structural properties.

(1R,2R,3S,4S,5S,6S)-1,2,3,4,5,6-Cyclohexanehexol can be synthesized via a stereoselective hydrogenation of a suitable isomer of cyclohexanone oxime. Commonly, this process involves the use of a chiral catalyst to achieve high enantioselectivity. The yield is generally around 70-80%, and the purity can be improved through recrystallization.

(1R,2R,3S,4S,5S,6S)-1,2,3,4,5,6-Cyclohexanehexol is primarily used in the pharmaceutical industry for the synthesis of chiral intermediates and pharmaceuticals. It is also used in the polymer industry for the modification of polymer properties and in the sensor technology for the development of chemical sensors due to its unique structural features.

When handling (1R,2R,3S,4S,5S,6S)-1,2,3,4,5,6-Cyclohexanehexol, proper personal protective equipment (PPE) should be used, including gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight and flammable materials. Spills should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.