7-bromo-1H-indene(CAS: 16657-07-1)

7-Bromo-1H-indene (CAS: 16657-07-1) is a crystalline compound with a molecular weight of approximately 187.03 g/mol. It has limited solubility in water but is more soluble in organic solvents like dichloromethane and benzene. It exhibits typical reactivity for a substituted aromatic compound, showing basic properties with strong acids and acidic properties with strong bases. It is stable under normal laboratory conditions but should be stored in a dry place to prevent degradation.

7-Bromo-1H-indene is typically synthesized through bromination of 1H-indene in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction involves the electrophilic bromination of the indene ring, followed by quenching with a base. The yield can vary depending on the conditions, but a yield of about 80% can be achieved under optimal conditions. The reaction is exothermic, so temperature control is important.

7-Bromo-1H-indene (CAS: 16657-07-1) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug candidates. It also finds applications in the polymer industry for developing functionalized polymers. Additionally, it is used in the semiconductor industry for the production of organic semiconductors and sensors due to its aromatic and brominated properties.

When handling 7-bromo-1H-indene (CAS: 16657-07-1), one should wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood due to its potential for inhalation hazards. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.