Compound Q&A

How is 7-bromo-1H-indene (CAS: 16657-07-1) typically synthesized?

Answer

7-bromo-1H-indene
7-Bromo-1H-indene is typically synthesized through bromination of 1H-indene in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction involves the electrophilic bromination of the indene ring, followed by quenching with a base. The yield can vary depending on the conditions, but a yield of about 80% can be achieved under optimal conditions. The reaction is exothermic, so temperature control is important.

About

CAS No 16657-07-1
English Name 7-bromo-1H-indene
Molecular Formula C9H7Br
Molecular Weight 195.06 g/mol
SMILES Brc1cccc2C=CCc21
InChIKey JTRQKQGKIYROIO-UHFFFAOYSA-N
Last Updated: 2025-10-23 07:31

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