5'-Deoxy-5-fluorouridine(CAS: 3094-09-5)

5'-Deoxy-5-fluorouridine (5'-DFUR) is a crystalline compound with a molecular weight of approximately 193.14 g/mol. It has a solubility of about 10 mg/mL in water and is relatively stable in acidic and neutral solutions. However, it is susceptible to hydrolysis in basic conditions. The compound shows limited reactivity towards nucleophilic substitutions and can be used as a fluorinated analog in various chemical reactions.

5'-Deoxy-5-fluorouridine (5'-DFUR) is commonly synthesized via the fluoroalkylation of 5'-deoxyuridine. The reaction typically uses fluoride sources like sodium fluoride and is catalyzed by a phase-transfer catalyst. The yield is usually around 70-80%, and the selectivity for the desired product is high. This method allows for the controlled introduction of a fluorine atom into the molecule, making it a valuable intermediate in medicinal chemistry.

5'-Deoxy-5-fluorouridine (5'-DFUR) is primarily used in the pharmaceutical industry due to its potential antiviral and anticancer properties. It is also studied in academic research for its use as a bioisostere in drug design. Additionally, its chemical structure makes it interesting for applications in polymer science and as a precursor in the synthesis of other fluorinated compounds.

When handling 5'-Deoxy-5-fluorouridine (5'-DFUR), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up according to the Material Safety Data Sheet (MSDS) guidelines, and the compound should be stored in a cool, dry place away from direct sunlight. Always refer to the latest SDS for detailed safety information.