How is 5'-Deoxy-5-fluorouridine (CAS: 3094-09-5) typically synthesized?

5'-Deoxy-5-fluorouridine (5'-DFUR) is commonly synthesized via the fluoroalkylation of 5'-deoxyuridine. The reaction typically uses fluoride sources like sodium fluoride and is catalyzed by a phase-transfer catalyst. The yield is usually around 70-80%, and the selectivity for the desired product is high. This method allows for the controlled introduction of a fluorine atom into the molecule, making it a valuable intermediate in medicinal chemistry.