2-Methyl-7-nitro-2H-indazole(CAS: 13436-58-3)

2-Methyl-7-nitro-2H-indazole is a crystalline solid with a molecular weight of approximately 213.09 g/mol. It has a melting point of around 188-190°C. The compound is slightly soluble in water but soluble in organic solvents like methanol and ethanol. It exhibits moderate reactivity towards nucleophiles and reducing agents, making it useful in various chemical transformations.

2-Methyl-7-nitro-2H-indazole is typically synthesized via a nitration process of 2-methyl-2H-indazole. The reaction involves the use of nitric acid in an appropriate solvent at elevated temperatures. The yield is generally good, and the selectivity towards the nitro product is high. Various mild conditions can be employed to improve the reaction kinetics and selectivity.

2-Methyl-7-nitro-2H-indazole is used in the pharmaceutical industry for the synthesis of drug intermediates due to its reactivity and stability. It also finds applications in the sensor industry, particularly in the development of gas sensors, and in the semiconductor industry as a precursor for functional materials. Additionally, it is utilized in polymer synthesis for the development of advanced materials.

Proper handling of 2-Methyl-7-nitro-2H-indazole requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to vapors. In case of spillage, it should be handled carefully using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage procedures.