(4-(tert-Butoxycarbonyl)phenyl)boronic acid(CAS: 850568-54-6)

(4-(tert-Butoxycarbonyl)phenyl)boronic acid is a white to off-white crystalline solid with a molecular weight of approximately 340.47 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. This compound is known for its reactivity in boronate ester formation and its ability to participate in Suzuki coupling reactions.

(4-(tert-Butoxycarbonyl)phenyl)boronic acid is usually synthesized from tert-butoxycarbonyl phenyl boronic acid via a boronic acid protection step using tert-butoxycarbonyl chloride. The reaction is typically performed at room temperature in the presence of a base like triethylamine in a solvent such as dichloromethane or tetrahydrofuran. The purity and yield can be optimized by adjusting the reaction conditions and using appropriate purification techniques.

(4-(tert-Butoxycarbonyl)phenyl)boronic acid is primarily used in the pharmaceutical and polymer industries. It plays a crucial role in the synthesis of various drugs and polymers due to its reactivity in coupling reactions. Additionally, it is used in the development of sensors and semiconductors for its unique chemical properties.

When handling (4-(tert-Butoxycarbonyl)phenyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and storage guidelines.