1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1)(CAS: 86483-48-9)

1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride is a crystalline solid with a molecular weight of approximately 414.93 g/mol. It has a pKa of about 4.2 and is soluble in water. The compound is stable under normal laboratory conditions but reacts with strong bases. It has poor solubility in organic solvents like hexane and ethyl acetate, but is well-soluble in polar solvents such as methanol and ethanol.

1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride is synthesized via condensation of 6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid with cyclopropyl chloride in the presence of a base such as triethylamine. The reaction is carried out in acetonitrile at room temperature, with high selectivity and yield. The intermediate is then converted to the hydrochloride salt using hydrogen chloride gas.

1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride is used in the pharmaceutical industry for developing new antipsychotic drugs. It is also explored for its potential in sensor technology and semiconductor applications due to its unique chemical structure and properties.

When handling 1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store the compound in a well-ventilated area and use a fume hood during handling to minimize exposure to vapors. In case of a spill, contain the spill using absorbent material and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.