Compound Q&A
How is 1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (CAS: 86483-48-9) typically synthesized?
Answer
1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride is synthesized via condensation of 6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid with cyclopropyl chloride in the presence of a base such as triethylamine. The reaction is carried out in acetonitrile at room temperature, with high selectivity and yield. The intermediate is then converted to the hydrochloride salt using hydrogen chloride gas.
About
CAS No
86483-48-9
English Name
1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1)
Molecular Formula
C17H19ClFN3O3
Molecular Weight
367.81 g/mol
SMILES
c1c2c(cc(c1F)N3CCNCC3)n(cc(c2=O)C(=O)O)C4CC4.Cl
InChIKey
DIOIOSKKIYDRIQ-UHFFFAOYSA-N
Last Updated: 2025-09-09 19:18
