2-[(Trimethylsilyl)ethynyl]benzaldehyde(CAS: 77123-58-1)

2-[(Trimethylsilyl)ethynyl]benzaldehyde (CAS: 77123-58-1) is a crystalline solid with a molecular weight of approximately 237.4 g/mol. It is slightly soluble in water but readily soluble in organic solvents like ethanol and acetone. This compound is reactive, particularly towards nucleophiles and can undergo condensation reactions and elimination reactions.

2-[(Trimethylsilyl)ethynyl]benzaldehyde can be synthesized via Grignard reaction. The typical synthesis involves the reaction of phenylmagnesium bromide with ethynyltrimethylsilane. The process requires anhydrous conditions and is typically carried out in ether or THF. The yield is usually around 70-80%, and the product can be purified by recrystallization.

2-[(Trimethylsilyl)ethynyl]benzaldehyde (CAS: 77123-58-1) is used in the pharmaceutical industry for the synthesis of certain drugs and intermediates. It is also utilized in the semiconductor industry for doping materials and in the production of sensors due to its specific chemical reactivity.

When handling 2-[(Trimethylsilyl)ethynyl]benzaldehyde (CAS: 77123-58-1), it is essential to wear appropriate personal protective equipment (PPE) including gloves, laboratory coat, and safety goggles. The compound should be handled in a well-ventilated area or under a fume hood. In case of a spill, use appropriate spill kits, and consult the Material Safety Data Sheet (MSDS) for specific instructions.