5-Bromo-2,4-bis[(2-methyl-2-propanyl)oxy]pyrimidine(CAS: 19752-61-5)

5-Bromo-2,4-bis[(2-methyl-2-propanyl)oxy]pyrimidine is a white crystalline solid with a molecular weight of approximately 350.26 g/mol. It has a low solubility in water but is soluble in common organic solvents such as ethanol and acetone. The compound shows moderate reactivity towards nucleophiles and can be used in various chemical reactions. It is stable under normal conditions but should be stored in a dry place away from moisture.

5-Bromo-2,4-bis[(2-methyl-2-propanyl)oxy]pyrimidine is typically synthesized via the bromination of 2,4-bis[(2-methyl-2-propanyl)oxy]pyrimidine using a brominating agent like N-bromosuccinimide (NBS) and a suitable solvent such as acetonitrile. The reaction is monitored by TLC (thin-layer chromatography) and typically achieves a yield of around 70-80%. The use of a catalyst like azobisisobutyronitrile (AIBN) can enhance the selectivity and yield of the product.

5-Bromo-2,4-bis[(2-methyl-2-propanyl)oxy]pyrimidine is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It is also used in the polymer industry to enhance the properties of certain polymers. Additionally, it has applications in the sensor industry for the development of chemical sensors and in the semiconductor industry for the production of electronic materials.

When handling 5-Bromo-2,4-bis[(2-methyl-2-propanyl)oxy]pyrimidine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up using appropriate absorbent materials and the area should be well ventilated. It is recommended to consult the Safety Data Sheet (SDS) for detailed handling and disposal guidelines.