2-Chloro-1,3-benzoxazole(CAS: 615-18-9)

2-Chloro-1,3-benzoxazole (CAS: 615-18-9) is a crystalline solid with a molecular weight of approximately 164.58 g/mol. It has a high solubility in organic solvents such as dichloromethane and acetone. Chemically, it is relatively stable but can undergo electrophilic aromatic substitution reactions. It is moderately reactive and can be used in various synthetic routes.

2-Chloro-1,3-benzoxazole (CAS: 615-18-9) is commonly synthesized by the condensation of 3-chlorobenzaldehyde with oxamide. The process involves heating the mixture under reflux to promote the formation of the oxazole ring. Other methods include the reaction of benzoyl chloride with chlorobenzene in the presence of a base, yielding a high yield of the product.

2-Chloro-1,3-benzoxazole (CAS: 615-18-9) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the production of dyes and pigments, as well as in the development of materials for sensors and semiconductors due to its unique electronic properties.

When handling 2-Chloro-1,3-benzoxazole (CAS: 615-18-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using the appropriate absorbent materials, and the area should be thoroughly rinsed. Refer to the safety data sheet (SDS) for detailed handling and disposal instructions.