2-Chloro-1-(3-chlorophenyl)ethanone(CAS: 21886-56-6)

2-Chloro-1-(3-chlorophenyl)ethanone (CAS: 21886-56-6) is a white crystalline solid with a molecular weight of approximately 212.03 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. This compound is relatively stable under normal conditions but can undergo hydrolysis and chlorination under acidic or basic conditions. It is used in various chemical processes and has a pKa of around 6.5.

2-Chloro-1-(3-chlorophenyl)ethanone (CAS: 21886-56-6) can be synthesized via the acylation of 3-chlorophenylmethanol with chloroacetyl chloride. The reaction is catalyzed by a Lewis acid such as aluminum chloride. The yield is typically around 70-80%. The process requires careful monitoring of temperature and pH to ensure high selectivity and yield.

2-Chloro-1-(3-chlorophenyl)ethanone (CAS: 21886-56-6) is primarily used in the pharmaceutical and fine chemical industries. It serves as an important intermediate in the synthesis of various organic compounds, including pharmaceuticals. Additionally, it finds applications in the production of dyes, polymers, and other chemical products.

When handling 2-Chloro-1-(3-chlorophenyl)ethanone (CAS: 21886-56-6), it is essential to use proper Personal Protective Equipment (PPE), including gloves, goggles, and a lab coat. This compound should be handled in a fume hood to minimize exposure to vapors. In case of a spill, neutralize any acid or base and dispose of the material according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.