6-Bromo-4-quinolinol(CAS: 145369-94-4)

6-Bromo-4-quinolinol (CAS: 145369-94-4) is a crystalline compound with a molecular weight of approximately 220.03 g/mol. It has a pKa of about 7.4 in aqueous solution and is slightly soluble in water. The compound is relatively stable in air but can be reactive towards strong oxidizing agents. It is a key intermediate in the synthesis of various pharmaceuticals and can be used in organic reactions.

6-Bromo-4-quinolinol (CAS: 145369-94-4) is typically synthesized via a bromination reaction of 4-quinolinol. Common methods include the use of N-bromosuccinimide (NBS) in the presence of a radical initiator like AIBN. The reaction is conducted in an inert solvent like dichloromethane. This method provides a yield of up to 85% and is selective for the bromination at the 6-position of the quinoline ring.

6-Bromo-4-quinolinol (CAS: 145369-94-4) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It also finds applications in the development of organic semiconductors and sensors due to its unique properties. Additionally, it is explored in the polymer industry for its potential use in the development of new materials.

When handling 6-Bromo-4-quinolinol (CAS: 145369-94-4), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate materials, and the area should be thoroughly washed. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.