O-Methyl Atorvastatin Calcium Salt(CAS: 887196-29-4)

O-Methyl Atorvastatin Calcium Salt (CAS: 887196-29-4) is a white crystalline powder with a molecular weight of approximately 644.86 g/mol. It is sparingly soluble in water and ethanol but soluble in dimethyl sulfoxide (DMSO). The compound is thermally stable but can react with acids to form calcium salts, which may affect its crystalline structure. It is primarily used in the pharmaceutical industry for cholesterol-lowering treatments.

O-Methyl Atorvastatin Calcium Salt (CAS: 887196-29-4) is typically synthesized through a multi-step process involving the key intermediate atorvastatin, which is then methylated and converted to the calcium salt. Common catalysts include aluminum chloride, and the reaction conditions are optimized for high yield and selectivity. The process involves protection of functional groups to ensure desired regioselectivity.

O-Methyl Atorvastatin Calcium Salt (CAS: 887196-29-4) is primarily used in the pharmaceutical industry for the treatment of hyperlipidemia and cardiovascular diseases. It is also of interest in research applications for its potential in studying lipid metabolism and cholesterol regulation. Additionally, it may find applications in biochemistry and molecular biology research.

When handling O-Methyl Atorvastatin Calcium Salt (CAS: 887196-29-4), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of spills, use gloves and a fume hood for safety, and follow the Material Safety Data Sheet (MSDS/SDS) for proper disposal. Always ensure adequate ventilation in the laboratory to prevent inhalation risks.