4-Bromo-6-methylpyridine-2-carbonitrile(CAS: 886372-53-8)

4-Bromo-6-methylpyridine-2-carbonitrile is a crystalline solid with a molecular weight of approximately 232.04 g/mol. It is slightly soluble in water but more soluble in organic solvents like methanol, ethanol, and dimethylformamide. Chemically, it is less reactive towards strong bases and acids, but can undergo nucleophilic substitution reactions under appropriate conditions. It has a melting point of around 125-127°C and exhibits a faintly aromatic odor.

4-Bromo-6-methylpyridine-2-carbonitrile is commonly synthesized via a multi-step process starting from 6-methylpyridine-2-carbonitrile. The bromination of the nitrogen atom is usually achieved using N-bromosuccinimide (NBS) in the presence of a radical initiator like benzoyl peroxide. The reaction is carried out in an inert solvent such as dichloromethane, and the product is typically obtained in good to high yield with high selectivity.

4-Bromo-6-methylpyridine-2-carbonitrile finds applications in various industries. It is used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the production of antiviral and antitumor drugs. Additionally, it is employed in the development of sensors and semiconductors due to its unique electronic properties. Its role in polymer chemistry is also notable, where it serves as a functional monomer for the synthesis of advanced materials.

When handling 4-Bromo-6-methylpyridine-2-carbonitrile, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, immediately stop work, evacuate the area, and clean up using appropriate absorbent materials. Always consult the Material Safety Data Sheet (MSDS) for detailed safety guidelines and emergency procedures.