(2,3-Difluorophenyl)boronic acid(CAS: 121219-16-7)

(2,3-Difluorophenyl)boronic acid (CAS: 121219-16-7) is a white crystalline powder with a molecular weight of approximately 183.07 g/mol. It has a solubility of about 1.8 g/L in water and is slightly soluble in common organic solvents. It is moderately reactive, particularly in boronate ester formation and other organoboron reactions. It is stable under normal conditions but should be stored in a dry, cool place away from direct sunlight.

(2,3-Difluorophenyl)boronic acid is commonly synthesized via the reduction of 2,3-difluorophenylboronic ester using a reducing agent like lithium aluminum hydride (LAH) in an inert solvent such as tetrahydrofuran (THF). The yield is typically around 80-90%, and the reaction is carried out under anhydrous conditions to ensure high purity.

(2,3-Difluorophenyl)boronic acid (CAS: 121219-16-7) is primarily used in the pharmaceutical industry for the synthesis of complex organic molecules and in polymer chemistry for the development of functional materials. It also finds applications in sensor technology and semiconductor manufacturing due to its reactivity in boronate ester formation.

When handling (2,3-Difluorophenyl)boronic acid (CAS: 121219-16-7), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to protect against skin and eye contact. Store it in a fume hood to minimize inhalation risk. Refer to the Material Safety Data Sheet (MSDS) for detailed information on handling, storage, and emergency procedures. Ensure proper ventilation and avoid contact with water and moisture.