2-Bromo-4,5-difluorophenylacetic acid(CAS: 883502-07-6)

2-Bromo-4,5-difluorophenylacetic acid (CAS: 883502-07-6) is a white crystalline solid with a molecular weight of approximately 262.03 g/mol. It has a low solubility in water (about 0.1 g/L) but is more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong bases to form the corresponding salt. It displays moderate reactivity with nucleophiles under certain conditions.

2-Bromo-4,5-difluorophenylacetic acid can be synthesized by bromination of 4,5-difluorophenylacetic acid using N-bromosuccinimide (NBS) in the presence of a suitable solvent like acetonitrile. The reaction is typically carried out under light or UV irradiation. The yield can be up to 90% with good selectivity towards the bromo substitution.

2-Bromo-4,5-difluorophenylacetic acid (CAS: 883502-07-6) is primarily used in pharmaceuticals for the synthesis of various drug candidates. It is also utilized in the polymer industry for developing high-performance materials. Its unique chemical structure makes it valuable in the sensor and semiconductor industries for specific applications requiring fluorinated aromatics.

When handling 2-Bromo-4,5-difluorophenylacetic acid (CAS: 883502-07-6), proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, it should be handled with care, following the safety data sheet (SDS) guidelines. Immediate decontamination of the spill area is necessary, and the area should be thoroughly cleaned.