Ethyl 4-hydroxy-6-methyl-3-quinolinecarboxylate(CAS: 85418-82-2)

Ethyl 4-hydroxy-6-methyl-3-quinolinecarboxylate (CAS: 85418-82-2) is a crystalline compound with a molecular weight of approximately 242.23 g/mol. It has a low solubility in water (2.5 g/100 mL at 20°C) and higher solubility in organic solvents like ethanol and acetone. The compound is reactive towards bases and can undergo hydrolysis. It is not flammable but may react with strong oxidizing agents.

Ethyl 4-hydroxy-6-methyl-3-quinolinecarboxylate (CAS: 85418-82-2) can be synthesized by the condensation of 4-hydroxy-6-methyl-3-quinolinecarboxylic acid with ethylamine followed by esterification. The reaction is typically carried out in the presence of a catalyst like hydrochloric acid to promote the esterification step. The yield is around 75-80% with good selectivity.

Ethyl 4-hydroxy-6-methyl-3-quinolinecarboxylate (CAS: 85418-82-2) is used in the pharmaceutical industry for the synthesis of certain drug candidates, particularly those involving quinoline derivatives. It also has applications in the polymer industry for modifying the properties of polymers and in the development of sensors and semiconductors due to its unique chemical structure.

When handling Ethyl 4-hydroxy-6-methyl-3-quinolinecarboxylate (CAS: 85418-82-2), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbent materials and the area should be washed down with water. Always consult the Safety Data Sheet (SDS) for specific guidance on handling and storage.