2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1-isoindolinecarboxylic acid(CAS: 221352-46-1)

2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1-isoindolinecarboxylic acid is a white crystalline solid with a molecular weight of approximately 302.38 g/mol. It has a low solubility in water but is soluble in most organic solvents. The compound is moderately reactive, particularly towards nucleophiles. It can be purified by recrystallization and is stable under normal conditions but should be stored away from moisture.

2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1-isoindolinecarboxylic acid can be synthesized via a multi-step process involving the protection of an alcohol followed by the formation of an ester. Common reagents include N,N-dimethylformamide (DMF) and 4-dimethylaminopyridine (DMAP) as a catalyst. The yield is typically around 70-80%, and the reaction is carried out under mild conditions to ensure high selectivity.

2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1-isoindolinecarboxylic acid is used in the pharmaceutical industry for the development of certain drug candidates. It also finds applications in the production of certain polymers and as a chemical intermediate in organic synthesis. Additionally, it is used in the synthesis of materials for sensors and semiconductors, though its specific roles in these industries are limited.

When handling 2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1-isoindolinecarboxylic acid, it is essential to wear protective equipment such as gloves, safety glasses, and a lab coat. This compound should be stored in a dry, well-ventilated area away from moisture. Fume hoods should be used during operations to minimize exposure. In case of a spill, it should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and proper handling procedures.