Ethyl 4-hydroxy-6-methoxy-3-quinolinecarboxylate(CAS: 77156-78-6)

Ethyl 4-hydroxy-6-methoxy-3-quinolinecarboxylate (CAS: 77156-78-6) is a crystalline solid with a molecular weight of approximately 264.28 g/mol. It is slightly soluble in water and ethanol but more soluble in organic solvents like dichloromethane and acetonitrile. This compound exhibits good reactivity towards nucleophiles and can be used in various chemical transformations. It has a pKa of around 4.5, making it moderately acidic.

Ethyl 4-hydroxy-6-methoxy-3-quinolinecarboxylate (CAS: 77156-78-6) can be synthesized through a multistep process involving the protection of a carboxylic acid, subsequent substitution reactions, and deprotection. Commonly, this involves protecting the carboxylic acid with an acylating agent, followed by a nucleophilic substitution reaction with a 4-hydroxy-6-methoxy-3-quinoline methyl ether. The process typically yields a clean product with high selectivity and reasonable to good yields.

Ethyl 4-hydroxy-6-methoxy-3-quinolinecarboxylate (CAS: 77156-78-6) is primarily used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also finds applications in the polymer industry as a monomer for specialized polymer formulations. Additionally, it is used in the development of sensors and semiconductors due to its unique chemical properties and functionality.

When handling Ethyl 4-hydroxy-6-methoxy-3-quinolinecarboxylate (CAS: 77156-78-6), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation of vapors. Ensure proper storage in a cool, dry place, away from flammable materials. In case of a spill, immediately clean up using appropriate spill kits and consult the Safety Data Sheet (SDS) for detailed instructions.