Methyl 6-formylnicotinate(CAS: 10165-86-3)

Methyl 6-formylnicotinate (CAS: 10165-86-3) is a white crystalline solid with a molecular weight of approximately 174.23 g/mol. It has a melting point of 150-152°C and is soluble in ethanol and acetone. It is less soluble in water. The compound is relatively stable under normal conditions but can react with strong bases to form 6-formylnicotinic acid. It is also susceptible to hydrolysis in the presence of water and heat.

Methyl 6-formylnicotinate (CAS: 10165-86-3) can be synthesized via the formylation of methyl nicotinate using a formylating agent such as formic anhydride in the presence of a catalyst like anhydrous aluminum chloride. The reaction involves the addition of formyl groups to the nicotinic acid structure, followed by esterification with methyl alcohol. The yield and selectivity of the reaction can be optimized by controlling the reaction conditions.

Methyl 6-formylnicotinate (CAS: 10165-86-3) is primarily used in the pharmaceutical industry for the synthesis of certain intermediates and drugs. It may also be used in the manufacturing of organic compounds and as a reagent in analytical chemistry. The compound might have applications in the development of new materials and sensors.

When handling Methyl 6-formylnicotinate (CAS: 10165-86-3), it is important to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be used in a well-ventilated area or under a fume hood to avoid inhalation. Spills should be cleaned up with appropriate absorbent materials and the area should be thoroughly washed. Always consult the Safety Data Sheet (SDS) for detailed handling and storage information.