(-)-Blebbistatin(CAS: 856925-71-8)

(-)-Blebbistatin is a crystalline compound with a molecular weight of approximately 441.34 g/mol. It has a solubility of about 0.25 mg/mL in DMSO. Chemically, it is relatively stable but can be sensitive to acidic conditions. It has been used in biological assays due to its specific inhibition of myosin II ATPase activity.

(-)-Blebbistatin is typically synthesized via a multi-step process involving organic transformations such as alkylation, hydrolysis, and oxidation. The key steps involve the preparation of an intermediate compound from blebbistatin, followed by enantioselective synthesis using chiral catalysts to achieve high yield and selectivity.

(-)-Blebbistatin is primarily used in the pharmaceutical and research industries for its role in inhibiting myosin II ATPase activity. It is also utilized in the development of drugs targeting muscle contraction and in biotechnological applications for molecular biology research.

When handling (-)-Blebbistatin, it is important to use personal protective equipment such as gloves and goggles. Store it in a cool, dark place, and avoid exposure to moisture and acidic conditions. In case of spill, immediately clean up and consult the Safety Data Sheet (SDS) for further instructions. Ensure adequate ventilation and work in a fume hood when performing experiments.