1-Bromo-3-fluoro-5-iodobenzene(CAS: 845866-85-5)

1-Bromo-3-fluoro-5-iodobenzene (CAS: 845866-85-5) is a crystalline solid with a molecular weight of approximately 350.43 g/mol. It is sparingly soluble in water but more soluble in organic solvents like dichloromethane and acetone. The compound exhibits moderate reactivity due to the presence of a fluorine and an iodine substituent, making it susceptible to nucleophilic and electrophilic substitution reactions.

1-Bromo-3-fluoro-5-iodobenzene can be synthesized via the sequential bromination and iodination of 3-fluorobenzoic acid. The process involves the use of N-bromosuccinimide (NBS) for bromination and N-iodosuccinimide (NIS) for iodination, both catalyzed by light. The yield is typically around 70-80%, and the reaction is carried out in an inert atmosphere to prevent side reactions.

1-Bromo-3-fluoro-5-iodobenzene (CAS: 845866-85-5) is primarily used in pharmaceutical and fine chemical industries for the synthesis of various intermediates and compounds. It also finds applications in the polymer industry for functionalizing polymers and in the development of new materials with specific properties.

When handling 1-Bromo-3-fluoro-5-iodobenzene (CAS: 845866-85-5), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed guidelines on handling and disposal.