4-Bromo-2-chloro-5-fluorobenzoic acid(CAS: 64742-95-6)

4-Bromo-2-chloro-5-fluorobenzoic acid is a crystalline solid with a molecular weight of approximately 267.02 g/mol. It has a low solubility in water (0.3 g/L at 20°C) but dissolves well in organic solvents like ethanol and acetonitrile. This compound is known for its reactivity, particularly towards nucleophilic substitution reactions at the aromatic ring.

4-Bromo-2-chloro-5-fluorobenzoic acid is synthesized via an electrophilic aromatic substitution route. A common method involves bromination of 2-chloro-5-fluorobenzoic acid with bromine in the presence of a Lewis acid catalyst, such as aluminum bromide. The yield can be increased by optimizing reaction conditions and using a suitable solvent.

4-Bromo-2-chloro-5-fluorobenzoic acid is used in pharmaceuticals for the synthesis of intermediates and in analytical chemistry for sensor applications. Its role in polymer synthesis and semiconductor manufacturing is also recognized, but on a smaller scale compared to pharmaceutical and analytical uses.

When handling 4-Bromo-2-chloro-5-fluorobenzoic acid, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store the compound in a cool, well-ventilated area. Work in a fume hood to minimize exposure. In case of a spill, immediately clean up using appropriate absorbents, and refer to the Safety Data Sheet (SDS) for detailed instructions.