1-Chloro-3-iodo-5-(trifluoromethyl)benzene(CAS: 1189352-83-7)

1-Chloro-3-iodo-5-(trifluoromethyl)benzene (CAS: 1189352-83-7) is a crystalline solid with a molecular weight of approximately 355.03 g/mol. It has low water solubility and high solubility in organic solvents like dichloromethane and acetonitrile. This compound is moderately reactive, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but requires storage in a dry and cool environment to prevent degradation.

1-Chloro-3-iodo-5-(trifluoromethyl)benzene (CAS: 1189352-83-7) can be synthesized via a Friedel-Crafts alkylation followed by a nucleophilic substitution reaction. Commonly, chlorobenzene is reacted with iodine in the presence of aluminum chloride to form 1-chloro-3-iodobenzene, which is then treated with trifluoromethyl iodide to produce the target compound. This synthesis typically yields a good to moderate percentage of the desired product, with careful control of reaction conditions ensuring high selectivity.

1-Chloro-3-iodo-5-(trifluoromethyl)benzene (CAS: 1189352-83-7) is utilized in the pharmaceutical and polymer industries. Its unique chemical structure makes it a valuable intermediate for synthesizing complex organic compounds, particularly in the development of new medications and materials with advanced properties. It is also used in the production of sensors and semiconductors due to its high stability and selectivity.

When handling 1-Chloro-3-iodo-5-(trifluoromethyl)benzene (CAS: 1189352-83-7), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be promptly cleaned up with appropriate absorbents, and the area should be flushed with water. Always refer to the safety data sheet (SDS) for specific precautionary measures and emergency response guidelines.