How is 1-Chloro-3-iodo-5-(trifluoromethyl)benzene (CAS: 1189352-83-7) typically synthesized?

1-Chloro-3-iodo-5-(trifluoromethyl)benzene (CAS: 1189352-83-7) can be synthesized via a Friedel-Crafts alkylation followed by a nucleophilic substitution reaction. Commonly, chlorobenzene is reacted with iodine in the presence of aluminum chloride to form 1-chloro-3-iodobenzene, which is then treated with trifluoromethyl iodide to produce the target compound. This synthesis typically yields a good to moderate percentage of the desired product, with careful control of reaction conditions ensuring high selectivity.