3-Hydroxy-1,2-propanediyl bis(2-methylacrylate)(CAS: 1830-78-0)

3-Hydroxy-1,2-propanediyl bis(2-methylacrylate) is a colorless to pale yellow liquid with a molecular weight of approximately 242.28 g/mol. It has a pKa of around 4.5 and is soluble in common organic solvents like ethanol and acetone. The compound is reactive towards inorganic bases and exhibits moderate reactivity with common functional groups. It crystallizes in the orthorhombic system and has a melting point of about 55°C.

3-Hydroxy-1,2-propanediyl bis(2-methylacrylate) is synthesized through an esterification reaction between 2-methylacrylic acid and 1,2-propanediol. Commonly, this reaction is catalyzed by a sulfuric acid or toluene sulfonic acid, with a yield of around 85%. The reaction is typically carried out at room temperature and the product is isolated by washing, drying, and distillation.

3-Hydroxy-1,2-propanediyl bis(2-methylacrylate) is used in the pharmaceutical, polymer, and sensor industries. It serves as a monomer for polymer synthesis, particularly in the production of acrylic resins. In pharmaceuticals, it can be used as a precursor for the synthesis of certain drugs. Its sensitivity to moisture and air necessitates its use in applications where these factors are controlled.

When handling 3-Hydroxy-1,2-propanediyl bis(2-methylacrylate), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and heat sources. Spills should be handled with care, using appropriate absorbent materials, and the area should be properly cleaned. Safety data sheets (SDS) should be readily available for reference.