2-Amino-5-cyanobenzoic acid(CAS: 99767-45-0)

2-Amino-5-cyanobenzoic acid is a crystalline compound with a molecular weight of approximately 179.08 g/mol. It has a melting point of 235-236°C and is slightly soluble in water. It reacts with bases to form salts and is prone to hydrolysis under acidic conditions. The compound is stable under normal conditions but should be handled with care due to its sensitivity to moisture and light.

2-Amino-5-cyanobenzoic acid can be synthesized through a multi-step process involving the coupling of 5-cyanobenzoic acid with an amine. Commonly, this involves reacting 5-cyanobenzoic acid with aniline using a coupling agent such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS) in the presence of a base like triethylamine. The yield can be up to 90% with good selectivity.

2-Amino-5-cyanobenzoic acid is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry as a monomer, and in the sensor and semiconductor industries for specific applications. Its unique chemical properties make it valuable in these sectors for its functional groups and reactivity.

When handling 2-Amino-5-cyanobenzoic acid, it is crucial to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to avoid exposure to fumes. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information.