3-Amino-3-(4-hydroxyphenyl)propanoic acid(CAS: 6049-54-3)

3-Amino-3-(4-hydroxyphenyl)propanoic acid (CAS: 6049-54-3) is a white to off-white crystalline solid with a molecular weight of approximately 221.22 g/mol. It has a pKa of about 4.2 in aqueous solution and is slightly soluble in water. It is reactive towards bases and can form salts. Common solvents include ethanol and methanol. It is also stable under normal storage conditions, but care should be taken to avoid strong acids and oxidizing agents.

3-Amino-3-(4-hydroxyphenyl)propanoic acid is typically synthesized through the coupling of 4-hydroxybenzaldehyde with alanine. The reaction involves the condensation of these two molecules in the presence of a suitable catalyst such as p-toluene sulfonic acid (p-TSA) or other Lewis acids. The yield is generally good with selectivity towards the desired diastereomer. The reaction is carried out in aqueous media, and the product can be isolated by recrystallization.

3-Amino-3-(4-hydroxyphenyl)propanoic acid (CAS: 6049-54-3) is primarily used in pharmaceuticals as an intermediate for the synthesis of various biologically active compounds. It is also used in the production of polymers and in some analytical applications as a chromophore or fluorophore. Additionally, it has potential applications in sensors and semiconductors due to its aromatic nature.

When handling 3-Amino-3-(4-hydroxyphenyl)propanoic acid (CAS: 6049-54-3), proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. This compound should be stored in a cool, dry place, away from strong acids and oxidizing agents. Spills should be cleaned up using appropriate decontamination procedures, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.